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Cpx (4 each), and clades A, F, CRF01_AE and CRF36_cpx (2 each). In addition, 22 of the studied viruses apparently had nef and gag genes from viruses belonging to different clades, with the majority (8/10) having either a nef or gag gene derived from CRF02_AG. Interestingly, five gag sequences (10 ) and three (5 ) nef sequences were neither obviously recombinant nor easily classifiable into any
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Ologyj.com/content/10/1/Page 2 ofparticularly relevant because they encode highly immunogenic proteins that are frequently included in candidate vaccines [9-11]. We sequenced 50 full length HIV-1 gag and 55 nef genes from 59 HIV-infected blood donors in Cameroon. To obtain a phylogenetic view of Cameroonian HIV diversity that explicitly accounted for the confounding effects of recombination, we pe
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Issecting the earliest evolutionary steps in the emergence of HIV-1M. Keywords: HIV-1 diversity, West central Africa, RDP3, Maximum likelihood, PHYMLFindings The Congo basin in west central Africa is thought to be the origin of HIV, where several cross-species transmission events from chimpanzees to humans occurred [1,2]. Cameroon, located in this region, has one of the most genetically diverse HI
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Tential impact of HIV-1 diversity on both vaccine development and the sustainability of antiretroviral therapies, it is particularly important that molecular epidemiological surveillance is continued in HIV diversity hotspots such as Cameroon. In this study we have focused on characterizing the diversity of gag and nef genes of Cameroonian HIV-1 isolates. These genes are?2013 Tongo et al.; license
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Anti-NS1 antibodies stimulating the release of IL-6, IL-8, and MCP-1 in an NFB-dependent manner. Correlated with antibody binding is the upregulation of ICAM1. ICAM1 upregulation can facilitate the adherence of PBMCs to the endothelium. Both NFB inhibitors and soluble NS1 to block the antiNS1 antibodies can able to block cytokine release in vitro[46]. Using ELISA flow cytometry, it can be shown th
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Tential impact of HIV-1 diversity on both vaccine development and the sustainability of antiretroviral therapies, it is particularly important that molecular epidemiological surveillance is continued in HIV diversity hotspots such as Cameroon. In this study we have focused on characterizing the diversity of gag and nef genes of Cameroonian HIV-1 isolates. These genes are?2013 Tongo et al.; license
1
Ologyj.com/content/10/1/Page 2 ofparticularly relevant because they encode highly immunogenic proteins that are frequently included in candidate vaccines [9-11]. We sequenced 50 full length HIV-1 gag and 55 nef genes from 59 HIV-infected blood donors in Cameroon. To obtain a phylogenetic view of Cameroonian HIV diversity that explicitly accounted for the confounding effects of recombination, we pe